期刊

Advanced Healthcare Materials

标题

Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model

作者

Wei Zhang, Jialin Chen,  Ludvig J. Backman,  Adam D. Malm and Patrik Danielson

摘要

Patrik Danielson and co-workers create a novel biomimetic 3D corneal model by optimizing the surface topography and mechanical strain similar to the microenvironment of native cornea. Compared to traditional 2D culture conditions, this 3D culture model, in the form of a collagen-modified, silk fibroin-patterned construct subjected to 3% dome-shaped strain, further enhances the expression of keratocyte and ECM markers, and better maintains the keratocyte phenotype, alignment and fusiform cell shape.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adhm.v6.5/issuetoc