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Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice
时间:2019-03-20 13:43:40
分类:Nano Letters
作品信息

期刊

Nano Letters

标题

Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

作者

Yu Zhao, Jinquan Cai, Zichen Liu, Yansheng Li, Chunxiong Zheng,  Yadan Zheng, Qun Chen, Hongyun Chen, Feihe Ma, Yingli An,  Lehui Xiao, Chuanlu Jiang,  Linqi Shi, Chunsheng Kang,  and Yang Liu

摘要

A novel design of nanocomposites that could attenuate the Aβ-induced neuron damage, regain the capability of the endocranial microglia to phagocytose Aβ, and eventually protect hippocampal neurons against apoptosis via forming the Aβ/nanocomposite coassembled nanoclusters instead of toxic Aβ oligomers.

原文链接

https://pubs.acs.org/doi/10.1021/acs.nanolett.8b03644

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