期刊

Blomedical Nanotechnology

标题

Multidimensional Theranostics for Tumor Fluorescence Imaging, Photoacoustic Imaging and Photothermal Treatment Based on Manganese Doped Carbon Dots

作者

Chuanyao Yang,  Yuan Li, Yanxue Yang, Rongsheng Tong, Lin He, Enwu Long, Lin Liang, Lulu Cai

摘要

Multidimensional theranostics have received a lot of attention because of their improved diagnostic accuracy and therapeutic diversity. In this study, we developed a kind of manganese doped nigrosine originated carbon dots (Mn-NCDs), with the average particle size of approximate 3 nm and the long emission wavelength of 653 nm. In vitro experiment demonstrated that Mn-NCDs could be well internalized by 4T1 cells, and the temperature of Mn-NCDs solution could rapidly rise from 23.1 °C to more than 50 °C when exposed to NIR laser, thus it could generate enough hyperthermia to efficiently destroy 4T1 cells. Furthermore, the in vivo fluorescent and photoacoustic imaging studies highlighted the applicability of Mn-NCDs in dual-mode tumor diagnosis. The prepared Mn-NCDs with long emission wavelength and photothermal anti-cancer effect exhibited great potential for dual-mode imaging and treatment of triple negative breast cancer.

原文链接

http://www.ingentaconnect.com/content/asp/jbn/2018/00000014/00000009/art00006