期刊

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标题

Cancer Diagnosis: A Universal Upconversion Sensing Platform for the Sensitive Detection of Tumour‐Related ncRNA through an Exo III‐Assisted Cycling Amplification Strategy

作者

Keying Zhang, Lin Yang, Feng Lu, Xingcai Wu, Jun‐Jie Zhu

摘要

In article number 1703858, Xingcai Wu, Jun‐Jie Zhu, and co‐workers report a universal and sensitive upconversion sensing nanoplatform for detecting tumor‐related non‐coding RNA. The sensitivity of the probe is improved by tuning the number of DNA units on the gold nanoparticles, and an exonuclease III‐assisted target cycling amplification strategy improves the sensitivity and achieves the universality of this sensing nanoplatform. Through this method, the expression level of microRNA‐21 in human breast cancer cell lysate is successfully measured, suggesting its potential in cancer diagnosis.

原文链接

https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201870044