期刊

Chem comm

标题

A C-HCR assembly of branched DNA nanostructures for amplified uracil-DNA glycosylase assays

作者

Jing Wang, Min Pan, Jie Wei, Xiaoqing Liua, Fuan Wang

摘要

An autonomous nonenzymatic DNA machine has been successfully engineered based on a two-layered cascaded hybridization chain reaction (C-HCR) circuit, in which the tandem outputs of the upstream HCR-1 unit activate the downstream HCR-2 unit to induce successive repeated hybridizations, generating branched DNA structures and enabling sensitive and selective detection of uracil-DNA glycosylase and its inhibitors.

原文链接

http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc07057h#!divAbstract