期刊

Chemical Communications

标题

Tetrabromobisphenol A (TBBPA) exhibits specific antimicrobial activity against Gram-positive bacteria without detectable resistance

作者

Fang Ji, Chang Wang, Huimin Wang, Guangliang Liu, Bolei Chen, Ligang Hu, Guibin Jiang, Maoyong Song and Yong Liang*

摘要

We report here the antimicrobial ability of tetrabromobisphenol A (TBBPA) against Gram-positive bacteria without detectable resistance. Microscopy imaging and gene analysis reveal that the bacterial cell wall is the target of TBBPA. Structure–activity studies of TBBPA and its analogues relate the observed antimicrobial activity to the halogen substitution neighboring the phenolic hydroxyl group.

原文链接

http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc00613f#!divAbstract