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Single-molecule imaging reveals the stoichiometry change of β2-adrenergic receptors by a pharmacological biased ligand
时间:2017-02-10 11:34:00
作品信息

期刊

Chem Comm

标题

Single-molecule imaging reveals the stoichiometry change of β2-adrenergic receptors by a pharmacological biased ligand

作者

Yahong Sun, Nan Li, Mingliang Zhang,ab Wei Zhou, Jinghe Yuan, Rong Zhao, Jimin Wu, Zijian Li, Youyi Zhang and Xiaohong Fang

摘要

The stoichiometry of the β2-adrenergic receptor (β2AR) was determined using single-molecule fluorescence imaging in living cells. The results showed that β2AR mainly existed as monomers under physiological conditions and exhibited β-arrestin-dependent dimerization upon stimulation with the pharmacological biased ligand carvedilol. The association of β2AR dimerization with biased signalling is revealed.

原文链接

http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc90233b

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