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Single-molecule imaging reveals the stoichiometry change of β2-adrenergic receptors by a pharmacological biased ligand
时间:2017-02-10 11:34:00
分类:Chem Comm
作品信息

期刊

Chem Comm


标题

Single-molecule imaging reveals the stoichiometry change of β2-adrenergic receptors by a pharmacological biased ligand


作者

Yahong Sun,a Nan Li,a Mingliang Zhang,ab Wei Zhou,a Jinghe Yuan,a Rong Zhao,a Jimin Wu,b Zijian Li,b Youyi Zhang*b and Xiaohong Fang*a


摘要

The stoichiometry of the β2-adrenergic receptor (β2AR) was determined using single-molecule fluorescence imaging in living cells. The results showed that β2AR mainly existed as monomers under physiological conditions and exhibited β-arrestin-dependent dimerization upon stimulation with the pharmacological biased ligand carvedilol. The association of β2AR dimerization with biased signalling is revealed.


原文链接

http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc90233b


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