期刊

Advanced Healthcare Materials

标题

Drug Delivery: Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales

作者

Shan Liu, Wei Wei, Bo Xie, Hua Yue, Dezhi Ni, Yali Bao, Guanghui Ma, Zhiguo G. Su

摘要

On page 2872, Guanghui Ma, Zhiguo Su, and co-workers construct a long-acting hyaluronidase (PH20-Fc) as a diffusion facilitator for typical anticancer agents: doxorubicin, trastuzumab, and gold nanorod. Although effective, the performances vary among these therapeutic agents. Trastuzumab benefits most from PH20-Fc with a best improvement in penetration and accumulation. Their systematic investigations thus reveal the importance of therapeutics size effect when using diffusion facilitator for anticancer therapy.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adhm.201670118/full