期刊
ChemMedChem

标题
Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation (ChemMedChem 6/2015) (page 934)

作者
Zhiqin Deng, Lianling Yu, Dr. Wenqiang Cao, Prof. Wenjie Zheng and Prof. Tianfeng Chen

摘要
novel Ru complex Ru(bnbp)2Cl2 (bnbp=2,6-bis- (6-nitrobenzimidazol-2-yl)pyridine) was synthesized and was found to enhance radiation-induced DNA damage through the overproduction of reactive oxygen species. Studies into its mechanism of action revealed it to cause G2M cell-cycle arrest and apoptosis by activating the p53 pathway. This study provides a rational design strategy for the development of benzimidazole-containing Ru complexes as potential radiosensitizers.

原文链接
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201500127/abstract