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Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics
时间:2017-02-09 13:28:00
作品信息

期刊
Macromolecular Rapid Communications

标题
Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics

作者
Liye Yang, Wenying Li, Yanyu Huang, Yangliang Zhou and Tianfeng Chen

摘要
A novel cancer-targeted prodrug BSeC-PEI-RGD with RGD peptide-conjugated selenocompound BSeC using PEI polymer as a linker is rationally designed and synthesized. BSeC-PEI-RGD shows selective cytotoxicity against cancer cells through induction of apoptosis with the involvement of intrinsic and extrinsic pathways. Moreover, the green fluorescence of BSeC-PEI-RGD supports its application potential in cancer diagnosis.

原文链接
http://onlinelibrary.wiley.com/doi/10.1002/marc.201500243/abstract

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