Macromolecular Rapid Communications
Rational Design of Cancer-Targeted Benzoselenadiazole by RGD Peptide Functionalization for Cancer Theranostics
Liye Yang, Wenying Li, Yanyu Huang, Yangliang Zhou and Tianfeng Chen
A novel cancer-targeted prodrug BSeC-PEI-RGD with RGD peptide-conjugated selenocompound BSeC using PEI polymer as a linker is rationally designed and synthesized. BSeC-PEI-RGD shows selective cytotoxicity against cancer cells through induction of apoptosis with the involvement of intrinsic and extrinsic pathways. Moreover, the green fluorescence of BSeC-PEI-RGD supports its application potential in cancer diagnosis.