期刊
Small

标题
CNT Biosafety: Multiwall Carbon Nanotubes Directly Promote Fibroblast–Myofibroblast and Epithelial–Mesenchymal Transitions through the Activation of the TGF-β/Smad Signaling Pathway (Small 4/2015) (page 385)

作者
Peng Wang, Yue Wang, Xin Nie, Céline Braïni, Ru Bai and Chunying Chen

摘要
The underlying mechanisms demonstrated by C. Chen and co-workers on page 446 show how multiwalled carbon nanotubes (MWCNTs) induce granuloma formation and fibrotic responses in vivo. MWCNT exposure can promote a fibroblast-to-myofibroblast conversion and the epithelial-mesenchymal transition (EMT) through the activation of the TGF-ß/Smad signaling pathway. Both of the cell transitions may play important roles in MWCNT-induced pulmonary fibrosis.

原文链接
http://onlinelibrary.wiley.com/doi/10.1002/smll.201303588/abstract