期刊

Advanced Materials

标题

Drug Delivery: Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene (Adv. Mater. 6/2015) (page 958)

作者

Tianyue Jiang, Wujin Sun, Qiuwen Zhu, Nancy A. Burns, Saad A. Khan, Ran Mo and Zhen Gu

摘要

A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL and DOX can be sequentially released toward the plasma membrane and nucleus, respectively.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adma.201404498/full