期刊

Angewandte Chemie

标题

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration (Angew. Chem. Int. Ed. 24/2014) (page 6278)

作者

Dr. Caoyun Ju, Dr. Ran Mo, Jingwei Xue, Lei Zhang, Zekai Zhao, Dr. Lingjing Xue, Prof. Qineng Ping and Dr. Can Zhang

摘要

A nanoparticle delivery system enables deep tumor penetration. As R. Mo, C. Zhang et al. show in their Communication on page 6253 ff., pH-sensitive nanogels (small yellow spheres) accumulate at the tumor tissues (red cells). After internalization, the nanogels swell (large spheres) releasing the encapsulated chemotherapeutics (blue). The nanogel contracts (small yellow spheres), is liberated from the dead cells (grape-like cells), infects neighboring cancer cells nearer the center of the tumor, and the process is repeated.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/anie.v53.24/issuetoc