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Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets†
时间:2017-02-07 14:05:00
作品信息

期刊

Angewandte Chemie

标题

Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

作者

Peng Zhao, Zitian Chen, izhou Li, Dawei Sun, Yuan Gao, Prof. Yanyi Huang, Prof. Xiaoyu Li

摘要

The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/anie.201404830/abstract

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