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Drug Delivery: Cancer-Targeted Monodisperse Mesoporous Silica Nanoparticles as Carrier of Ruthenium Polypyridyl Complexes to Enhance Theranostic Effects (Adv. Funct. Mater. 19/2014) (page 2737)
时间:2017-01-21 19:10:00
作品信息

期刊

Advanced Functional Materials

标题

Drug Delivery: Cancer-Targeted Monodisperse Mesoporous Silica Nanoparticles as Carrier of Ruthenium Polypyridyl Complexes to Enhance Theranostic Effects (Adv. Funct. Mater. 19/2014) (page 2737)

作者

Lizhen He, Yanyu Huang, Huili Zhu, Guanhua Pang, Wenjie Zheng, Yum-Shing Wong and Tianfeng Chen

摘要

In this study, T. Chen and co-workers present a cancer-targeted MSN drug-delivery system carrying ruthenium complexes (RuPOP@MSNs), that allows the direct fluorescence monitoring of the cellular uptake and localization of theranostic agents in cancer cells. On page 2754 the nanoparticles exhibit unprecedented enhanced cytotoxicity toward cancer cells overexpressing integrin receptors through the induction of apoptosis. Moreover, the strong autofluorescence of Ru complex extends the power of theranostics to a subcellular level.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adfm.v24.19/issuetoc

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