期刊

Advanced Materials

标题

Drug Delivery: Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy

作者

Jing Wang,Jing Liu,Ying Liu,Liming Wang,Mingjing Cao,Yinglu Ji,Xiaochun Wu,Yingying Xu,Bing Bai,Qing Miao,Chunying Chen,Yuliang Zhao

摘要

On page 8950, Y. Zhao and co-workers propose an insightful and attractive strategy for enhanced pathological permeability and retention (EPPR) effect in drug delivery. They fabricated a new Gd-hybridized plasmonic gold nanocomposite and then used a novel strategy by plasmonic feature-based localized and on-off controlled photothermal properties to increase the transportation and permeability of the nanocomposite (loaded with imaging agents and drugs) in the tumor interior, achieving high-sensitive multimodal imaging and simultaneously improving the therapeutic efficacy.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adma.201670285/abstract