期刊

Small

标题

Peptoids: Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization (Small 1/2017)

作者

Zijian Zhao, Ling Zhu, Haiyun Li, Peng Cheng, Jiaxi Peng, Yudan Yin, Yang Yang, Chen Wang, Zhiyuan Hu and Yanlian Yang

摘要

Antiamyloidogenic agents have promising application potential in AD therapies. In article number 1602857, L. Zhu, Z. Hu, Y. Yang, and co-workers present an Aβ42-binding agent amyloid inhibitory 1 (AIP1), demonstrate its inhibitory effect on Aβ42 oligomerization and fibrillation, and show that AIP1 rescue Aβ42-induced cytotoxicity through decreasing Aβ42 oligomer content is related to cell membrane permeability.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/smll.v13.1/issuetoc