期刊
JACS
标题
A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy
作者
Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, and Ling Peng
摘要
A small amphiphilic dendrimer is self-assembled into nanomicelles and formed stable nanoparticles with siRNA, then decorated with a peptide bearing a dual targeting warhead for homing in on cancer cells in tumor. This study offers new perspectives on the self-assembling dendrimer nanosystems for targeted delivery in nanomedicine.
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