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A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy
时间:2018-12-15 14:00:01
分类:JACS
作品信息

期刊

JACS

标题

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

作者

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, and Ling Peng

摘要

A small amphiphilic dendrimer is self-assembled into nanomicelles and formed stable nanoparticles with siRNA, then decorated with a peptide bearing a dual targeting warhead for homing in on cancer cells in tumor. This study offers new perspectives on the self-assembling dendrimer nanosystems for targeted delivery in nanomedicine.

原文链接

https://pubs.acs.org/doi/10.1021/jacs.8b10021

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