期刊

Science China Materials

标题

Isomerization and rearrangement of boriranes: from chemical rarities to functional materials

作者

Soren K. Mellerup, Suning Wang

摘要

Nanohybrids of carbon dots (CDs)/MnO2-PEG with pH/H2O2-responsivity were synthesized via the redox reaction between the CDs and KMnO4 followed by PEGylation. The as-prepared nanohybrids exhibit synchronously enhanced fluorescence, singlet oxygen generation, and MRI signal in the tumor microenvironment, while changing to “off state” in the normal physiological environment. In vitro and in vivo analyses reveal that the low-toxic CDs/MnO2-PEG nanohybrids can be applied as pH/H2O2-driven nanotheranostics for the concurrent bimodal MR/FL imaging-guided oxygen-elevated photodynamic therapy (PDT) of cancer. This work offers a new nanotheranostic candidate for modulating the unfavorable tumor microenvironment,particularly for the tumor-targeted PDT through precise  positioning and oxygen generation

原文链接

http://engine.scichina.com/publisher/scp/journal/SCMs/61/10?slug=browse