期刊

Advanced Materials

标题

A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System

作者

Di Wu,Meng Qin, Duo Xu, Lan Wang, Chaoyong Liu, Jie Ren, George Zhou, Chen Chen, Fengmei Yang, Yanyan Li, Yuan Zhao, Ruyi Huang, Sina Pourtaheri, Chunsheng Kang, Masakazu, Kamata Irvin S. Y. Chen, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu

摘要

A universal central nervous system (CNS)‐delivery platform is developed enabling the delivery of protein therapeutics to the brain via choline transporters and acetylcholine receptors. In article number 1807557, Zhanlong He, Jing Wen, Wei Chen, Yunfeng Lu, and co‐workers demonstrate that the protein therapeutics can effectively penetrate the blood–brain barrier in mice and nonhuman primates by encapsulating the proteins within nanocapsules with choline and acetylcholine analogues.

原文链接

https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201970127