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Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres
时间:2019-06-05 16:17:27
作品信息

期刊

Advanced Healthcare Materials

标题

Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres

作者

Lin Chen,Xiaobo Ma,Meng Dang,Heng Dong,Hongming Hu,Xiaodan Su,Wenfei Liu,Qing Wang,Yongbin Mou,Zhaogang Teng

摘要

In article number 1900039, Yongbin Mou, Zhaogang Teng, and co‐workers show that iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs) with core‐shell structure, high surface area, large mesopores and huge pore volume can initiate DC‐based T cell activation and tumor‐associated macrophage (TAM) polarization simultaneously. The combined T cell activation and macrophage polarization strategy based on the IO‐LPMONs elicits remarkable combined antitumor effects. This study demonstrates that the new‐synthesized IO‐LPMONs hold excellent potential as an immune modulator for cancer immunotherapy.

原文链接

https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201970041



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