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Covalent Bonding of an Electroconductive Hydrogel to Gold‐Coated Titanium Surfaces via Thiol‐ene Click Chemistry
时间:2020-09-17 16:51:59
作品信息

期刊

Macromolecular Materials and Engineering

标题

Covalent Bonding of an Electroconductive Hydrogel to Gold‐Coated Titanium Surfaces via Thiol‐ene Click Chemistry

作者

Guoxin Tan, Yan Liu, Lei Zhou, Kongyou Ouyang, Zhengao Wang, Peng Yu, Chengyun Ning

摘要

In the present study, the covalent bonding of electroconductive cross‐linked hydrogel networks with both electro‐properties and hydrogel characteristics to titanium surfaces via a UV‐initiated radical thiol‐ene click reaction is investigated. The electroconductive hydrogel layers are formed by the electropolymerization of pyrrole within the titanium implant‐supported gelatin methacrylate hydrogel. Characterization of the surface morphology of the layers reveals a unique rough macroporous structure. The hydrogel coating layer on the titanium surfaces possesses the desired characteristics of high electrochemical activity and high mechanical stability due to the effects of the chemical functionalization. Bone mesenchymal stem cells cultured on the hydrogel substrates exhibit high cell viability. This study is the first to demonstrate the potential of an electroconductive hydrogel as a surface coating on titanium implants for cell growth and provides a foundation for the development of new implantable bioelectronic devices.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/mame.201600296

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