Advanced Functional Materials
Osseointegration: Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis
Zhenzhen Wang, Yiming Niu, Xuejiao Tian, Na Yu, Xiaoyu Yin, Zhen Xing, Yurong Li, Lei Dong, Chunming Wang
In article number 2007408, Lei Dong, Chunming Wang, and co‐workers invent a “bridge‐burning” bioactive coating to sequentially turn on and off inflammation on bone implants. This coating first instructs host macrophages to activate bone cells to promote healing and then receives signals from bone cells to kill macrophages for higher safety. It improves bone‐implant integration in mice with osteoporosis.