期刊
Advanced Functional Materials
标题
Synergistic Chemotherapy: Bioengineered Dual-Targeting Protein Nanocage for Stereoscopical Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy
作者
Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan
摘要
In article number 2102004, Xiyun Yan, Kelong Fan, and co-workers present an amphiphilic multi-drug loading protein nanocage (Am-PNCage) with a dual-tumor targeting (CD71 and Integrin) property, which exhibits a spatiotemporally programmed cascade drug release pattern and kills drug-resistant tumor cells synergistically. It represents a novel promising protein cage nanocarrier platform for co-loading synergistic hydrophilic and hydrophobic drug pairs and targeted combination chemotherapy.
摘要
