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Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L
时间:2021-10-09 10:47:48
作品信息

期刊

Advanced Healthcare Materials

标题

Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L

作者

Xin-Bin Zhao, Yun-Ping Chen, Min Tan, Lan Zhao, Yuan-Yuan Zhai, Yan-Ling Sun, Yan Gong, Xi-Qiao Feng, Jing Du, Yu-Bo Fan,

摘要

Extracellular Matrix Stiffness

In article number 2100821 by Jing Du, Yu-Bo Fan, and co-workers, extracellular matrix (ECM) stiffness has profound effects on the regulation of cell functions. Stiff ECM enhances DNA methylation of pluripotent genes by the nuclear transport of DNA methyltransferase 3-like binding to Nanog promoter in mouse embryonic stem cells (mESCs). DNA methylation is a novel target for the mechanical sensing mechanism during mESCs–ECM interactions.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/adhm.202170076

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