Advanced Healthcare Materials
Extracellular Matrix Stiffness Regulates DNA Methylation by PKCα-Dependent Nuclear Transport of DNMT3L
Xin-Bin Zhao, Yun-Ping Chen, Min Tan, Lan Zhao, Yuan-Yuan Zhai, Yan-Ling Sun, Yan Gong, Xi-Qiao Feng, Jing Du, Yu-Bo Fan,
Extracellular Matrix Stiffness
In article number 2100821 by Jing Du, Yu-Bo Fan, and co-workers, extracellular matrix (ECM) stiffness has profound effects on the regulation of cell functions. Stiff ECM enhances DNA methylation of pluripotent genes by the nuclear transport of DNA methyltransferase 3-like binding to Nanog promoter in mouse embryonic stem cells (mESCs). DNA methylation is a novel target for the mechanical sensing mechanism during mESCs–ECM interactions.