期刊

Chemical Communications

标题

Reshaping the active pocket of promiscuous lactonases for degrading bulky organophosphate flame retardants

作者

Yuanyuan Zhang,  Xiaoyan Zhang, Huan Cheng, Mario Roque Huanca Nina, Jun Ge, Yunpeng Bai

摘要

Engineering of a promiscuous lactonase via semi-rational evolution gave a 1007-fold improvement in its catalytic activity in the degradation of triphenyl phosphate (TPHP). TPHP is a typical bulky organophosphate flame retardant (OPFR) and is widely used in industry. To the best of our knowledge, this is the first artificial enzyme capable of degrading OPFRs.

原文链接

https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc02657g