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Cation-Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy
时间:2021-11-18 11:08:07
作品信息

期刊

Advanced Materials

标题

Cation-Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy

作者

Tong Jiang,Yonghan Qiao,Weimin Ruan,Dongya Zhang,Qingshan Yang,Guoying Wang,Qunzhi Chen,Fengping Zhu,Jinlong Yin,Yan Zou,Rongjun Qian,Meng Zheng,Bingyang Shi

摘要

Tumor Therapy

In article number 2104779, Meng Zheng, Bingyang Shi, and co-workers develop a kind of polymeric siRNA micelle as an effective drug-delivery platform and potent RNAi nanomedicine for glioblastoma therapy. The siRNA micelles are capable of traversing the blood–brain barrier via transcytosis mediated by scavenger receptors, to subsequently target a brain tumor and then exert potent RNAi therapy or RNAi-Chemo synergistic therapy.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/adma.202170357

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