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Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy
时间:2021-12-27 11:16:16
作品信息

期刊

Chemical Communications

标题

Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

作者

Yiqiao Tian, Yanyu Huang, Pan Gao and Tianfeng Chen

摘要

A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.

原文链接

https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc04021d

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