期刊

Journal of Materials Chemistry B

标题

Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic

作者

Siming Yu, Kar-Him Luk, Siu-To Cheung, Kevin Wing-Hin Kwok, Ka-Hing Wong and Tianfeng Chen

摘要

Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.

原文链接

https://pubs.rsc.org/en/content/articlelanding/2018/tb/c8tb01084f