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Reprogramming Tumor-Associated Macrophages via ROS-Mediated Novel Mechanism of Ultra-Small Cu2−xSe Nanoparticles to Enhance Anti-Tumor Immunity
时间:2022-03-18 10:52:00
作品信息

期刊

Advanced Functional Materials

标题

Reprogramming Tumor-Associated Macrophages via ROS-Mediated Novel Mechanism of Ultra-Small Cu2−xSe Nanoparticles to Enhance Anti-Tumor Immunity

作者

Yanhui Zheng,Yaobao Han,Tingting Wang,Hanghang Liu,Qiao Sun,Shijun Hu,Jianquan Chen,Zhen Li

摘要

Reprogramming Tumor-Associated Macrophages

In article number 2108971, Zhen Li and co-workers find that ultra-small Cu2−xSe nanoparticles can effectively polarize tumor-associated macrophages (TAMs) from the tumor-supportive M2 phenotype into anti-tumor M1 phenotype to significantly boost anti-tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS-TRAF6-IRF5-IL-23 signaling pathway, rather than the classic ROS-NF-?B-iNOS pathway.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202270072


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