期刊
Advanced Functional Materials
标题
Reprogramming Tumor-Associated Macrophages via ROS-Mediated Novel Mechanism of Ultra-Small Cu2−xSe Nanoparticles to Enhance Anti-Tumor Immunity
作者
Yanhui Zheng,Yaobao Han,Tingting Wang,Hanghang Liu,Qiao Sun,Shijun Hu,Jianquan Chen,Zhen Li
摘要
Reprogramming Tumor-Associated Macrophages
In article number 2108971, Zhen Li and co-workers find that ultra-small Cu2−xSe nanoparticles can effectively polarize tumor-associated macrophages (TAMs) from the tumor-supportive M2 phenotype into anti-tumor M1 phenotype to significantly boost anti-tumor immunity through a novel mechanism. The nanoparticles can generate reactive oxygen species to trigger polarization through the novel ROS-TRAF6-IRF5-IL-23 signaling pathway, rather than the classic ROS-NF-?B-iNOS pathway.
原文链接
