Angewandte Chemie International Edition
Glutathione Depletion-Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor
Zhanwei Zhou,Huan Liang,Ruoxi Yang,Ying Yang,Jingwen Dong,Yongxiang Di,Prof. Minjie Sun
Glutathione (GSH) is abundant in “cold” tumors and adversely affects ferroptosis therapy and immune response. In their Research Article (e202202843), Minjie Sun and co-workers developed cinnamaldehyde-dimer-based vesicles (CDC dimersomes) capable of depleting intracellular GSH via Michael addition to potentiate the ferroptosis and immunotherapy of breast cancer by turning the “cold” tumor into a “hot” tumor. CDC is the first drug-dimer-based vesicle applied for immune activation, inspiring the future design of functional vesicles.