期刊
Exploration
标题
Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy
作者
Yanjie Liu, Wendie Wang, Dongya Zhang, Yajing Sun, Fangzhou Li, Meng Zheng, David B. Lovejoy, Yan Zou, Bingyang Shi
摘要
Yan Zou and co-workers present a temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine platform that achieves prolonged blood circulation time, excellent blood brain barrier (BBB) permeability, and multidimensional enhanced glioblastoma (GBM) synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models with significant extended survival rate and little side effects.
原文链接
