Chinese Chemical Letters
Near-infrared dyes, nanomaterials and proteins
Zong Chang, Feng Liu, Liang Wang, Mengying Deng, Chunhua Zhou, Qinchao Sun, JunChu
Taking the advantage of reduced scattering and low autofluorescence background, the NIR fluorescence probes, such as fluorescence proteins, organic molecules and nanoparticles, not only hold the promise of in vivo imaging of biological processes in physiology and pathology with high signal-to-noise ratio, but also for clinical diagnosis. In this review, we provide an overview of the recent progress on NIR probes, focusing on fundamental mechanisms of NIR dyes and nanoparticles, and protein engineering strategies for NIR proteins.