期刊

Advanced Science

标题

Collateral Effects: The CRISPR-Cas13a Gene-Editing System Induces Collateral Cleavage of RNA in Glioma Cells

作者

Qixue Wang, Xing Liu, Junhu Zhou, Chao Yang, Guangxiu Wang, Yanli Tan, Ye Wu, Sijing Zhang, Kaikai Yi, Chunsheng Kang

摘要

In article number 1901299, Chunsheng Kang and co-workers demonstrate the collateral effect of the CRISPR-Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR-Cas13a system induces death in EGFRvIII-overexpressing glioma cells. Furthermore, CRISPR-Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system.

原文链接

https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.201970124