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Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment
时间:2022-10-28 15:16:51
作品信息

期刊

Advanced Science

标题

Small Activating RNA Modulation of the G Protein-Coupled Receptor for Cancer Treatment 

作者

Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang,Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

摘要

Small Activating RNA Modulation

In article number 2200562, Ling Peng, Leo Tsz On Lee, and co-workers, report for the first time that small activating RNA (saRNA) delivered by amphiphilic dendrimer can effectively modulate a G protein-coupled receptors (GPCR), Mas receptor, for cancer treatment. This project provides not only a new strategy for cancer therapy, but also a new avenue to address undruggable GPCRs.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/advs.202270162

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