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Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post-Resection
时间:2022-11-25 17:24:41
作品信息

期刊

Advanced Functional Materials

标题

Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post-Resection

作者

Shuo Sun,Wei Gu,Haisi Wu,Qianqian Zhao,Shiyu Qian,Hong Xiao,Kun Yang,Jian Liu,Yu Jin,Chupeng Hu,Ye Gao,Huae Xu,Hongyi Liu,Jing Ji,Yun Chen

摘要

Flexible Optoelectronics

In article number 2205038, Huae Xu, Hongyi Liu, Jing Ji, Yun Chen, and co-workers present an injectable, reactive oxygen species-responsive therapeutic hydrogel (ADU-AAV-PD1@Gel), capable of sustained local release of soluble PD-1 (sPD-1) and STING agonist ADU-S100. The ADU-AAV-PD1@Gel combined with radiotherapy generates a robust antitumor immune response and induces long-term immune memory to prevent glioblastoma recurrence.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202270246

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