期刊
Advanced Materials Interfaces
标题
Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7
作者
Shiyu Sun, Cen Cao, Yaru Guo, Yi Hou, Yanze Meng, Yuman Li, Feng Mei, Zhewen Hu, Yao Li, Yuting Niu, Yiming Chen, Lili Chen, Ying Huang, Xuliang Deng
摘要
Sprouting Angiogenesis Deceleration
Deceleration of sprouting angiogenesis after vessel reconstruction is crucial for controlled tissue repair. As reported by Shiyu Sun, Cen Cao, and colleagues in article number 2201719, in bone defect healing, osteogenic-differentiated bone marrow stem cells contribute to sprouting angiogenesis deceleration by paracrine excreting insulin-like growth factor-binding protein 7 (IGFBP7), which inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. This study suggests the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.
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