期刊
Advanced Science
标题
A Brain-Targeting NIR-II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma
作者
Jing Zhang, Lulu Han, Haigang Wu, Yong Zhong, Ping Shangguan, Yisheng Liu, Mu He, Han Sun, Chenhui Song, Xin Wang, Yang Liu, Jiefei Wang, Lei Zheng, Bingyang Shi, Ben Zhong Tang
摘要
Near-Infrared Aggregation-Induced Emission Ferroptosis Molecule
A near-infrared (NIR) aggregation-induced emission ferroptosis molecule (TBTP-Au) is first designed by introducing Au(I) active center. The self-assembled TBTP-Au nanoparticles with targeted modification display superior NIR imaging performance to monitor the blood-brain barrier penetration of nanoparticles. The controlled release of TBTP-Au specifically activate the effective heme oxygenase-1-regulated ferroptosis to greatly prolong the survival of glioma-bearing mice. More details can be found in article number 2206333 by Jiefei Wang, Lei Zheng, Bingyang Shi, Ben Zhong Tang, and co-workers.
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