期刊
Advanced Functional Materials
标题
Chemokine-Based Injectable Navigation System for Enhancing CAR-T Cell Therapy Against Solid Tumors
作者
Wenjun Wan, Wenqing Han, Jin Chen, Yangjing Li, Lei Zhao, Mengqian Gao, Cui Shen, Ning Liu, Wenhao Deng, Siqi Ma, Lifang Cheng, Yiran Zheng
摘要
CAR-T Cell Therapy
In article number 2401161, Yiran Zheng and co-workers present a chemokine-based Injectable platform for boosting adoptive T cells' efficacy (CITE). The system substantially promotes the tumor-specific migration of injected CAR-T cells and boosts the function of infiltrated T cells, thus improving the efficacies of CAR-T cell therapy to solid tumors. CITE also enhances systemic anti-tumor immunity and elicits immune memory, enabling CITE to treat multimodal and recurrent tumors. CITE is broadly applicable to adoptive cell therapies.
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