期刊

Chemistry of Materials

标题

Conjugated Polymer with Aggregation-Directed Intramolecular Förster Resonance Energy Transfer Enabling Efficient Discrimination and Killing of Microbial Pathogens

作者

Shuxian Zhu, Xiaoyu Wang, Yu Yang, Haotian Bai, Qianling Cui, Han Sun, Lidong Li, Shu Wang

摘要

Rapid, effective differentiation and killing of microbial pathogens are major challenges in the diagnosis and treatment of infectious diseases. A novel system was developed based on the conjugated polymer, which enables efficient microbial pathogen discrimination and killing (see cover). The binding event of conjugated polymer to microorganism causes a change in the aggregation structure of conjugated polymer, which could be recognized by a change of its fluorescence signal by intramolecular fluorescence resonance energy transfer. This sensing strategy allowed rapid and sensitive distinction of microbial pathogens within 15 min. Furthermore, the microbial pathogens were efficiently killed by reactive oxygen species produced from conjugated polymer under irradiation. This methodology, which combines pathogen discrimination and killing, represents a promising alternative to current diagnostic platforms.

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