期刊
Angewandte Chemie
标题
Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets
作者
Peng Zhao, Zitian Chen, izhou Li, Dawei Sun, Yuan Gao, Prof. Yanyi Huang, Prof. Xiaoyu Li
摘要
The selection of DNA-encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement of modified and immobilized targets remains a significant disadvantage. With a terminal protection strategy and ligand-induced photo-crosslinking, we show that iterated selections of DNA-encoded libraries can be realized with unmodified and non-immobilized protein targets.
原文链接
http://onlinelibrary.wiley.com/doi/10.1002/anie.201404830/abstract