期刊

Advanced Functional Materials

标题

Biomedical Applications: Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light (Adv. Funct. Mater. 24/2013)

作者

Chao Wang,Liang Cheng,Yumeng Liu,Xiaojing Wang,Xinxing Ma,Zhaoyi Deng,Yonggang Li,Zhuang Liu

摘要

Smart charge-reversible upconversion nanoparticles are reported on page 3077 by Zhuang Liu and co-workers for pH-responsive, in vivo, near-infrared light excited photodynamic therapy. While stable under normal physiological pH, highly sensitive acid-induced charge conversion of the nanoparticles is observed in a slightly acidic tumor microenvironment, resulting in significantly enhanced cellular internalization of nanoparticles and remarkably improved photodynamic cancer cell killing in vitro and in vivo.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/adfm.201370119/abstract