期刊

Small

标题

Metallofullerenols: Polyhydroxylated Metallofullerenols Stimulate IL-1β Secretion of Macrophage through TLRs/MyD88/NF-κB Pathway and NLRP3 Inflammasome Activation (Small 12/2014) (page 2310)

作者

Zhiyun Chen, Ying Liu, Baoyun Sun, Han Li, Jinquan Dong, Lijuan Zhang, Liming Wang, Peng Wang, Yuliang Zhao and Chunying Chen

摘要

Metallofullerenols uptaken by macrophages can promote the production of inflammatory cytokines like IL-1β by triggering two signaling pathways indepentently. As reported on page 2362 by C. Chen and co-workers, fullerenols prime macrophages to express pro-IL-1β viaTLRs/MyD88 pathway and subsequently activate NF-κB. Importantly, they activate NLRP3 inflammasome in macrophages, which is required for processing pro-IL-1β into mature IL-1β. These findings contibute to better understanding their underlying mechanism of antitumor chemotherapeutics and good immunoregulatory effects.

原文链接

http://onlinelibrary.wiley.com/doi/10.1002/smll.v10.12/issuetoc