期刊

Advanced Materials

标题

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

作者

Lei Han, Chaoyong Liu, Hongzhao Qi, Junhu Zhou, Jing Wen, Di Wu, Duo Xu, Meng Qin, Jie Ren, Qixue Wang, Lixia Long, Yang Liu, Irvin Chen, Xubo Yuan, Yunfeng Lu, Chunsheng Kang

摘要

In article number 1805697, Xubo Yuan, Yunfeng Lu, Chunsheng Kang, and co‐workers report a platform technology that enables effective delivery of therapeutic monoclonal antibody (mAb) to the central nervous system (CNS) for brain‐tumor therapy. This is achieved by encapsulating the mAbs within nanocapsules that contain choline and acetylcholine analogues. The brain takes up these mAb nanocapsuels, which facilitates the delivery of mAb across the blood–brain barrier. This platform technology uncages the therapeutic power of mAbs for various CNS diseases that remain poorly treated.

原文地址

https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201970138