期刊
Advanced Materials
标题
Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy
作者
Xiaobo Jia,Yihua Zhang,Yu Zou,Yao Wang,Dechao Niu,Qianjun He,Zhangjian Huang,Weihong Zhu,He Tian,Jianlin Shi,Yongsheng Li
摘要
In article number 1704490, Zhangjian Huang, Yongsheng Li, and co-workers demonstrate a paradigm of dual intratumoral redox/enzyme-responsive NO-release nanomedicine for tumor-specific and high-efficacy cancer therapy by constructing a novel organic-inorganic composite nanomedicine through encapsulating a GSTπ-responsive NO-releasing prodrug, NPQ, into a redox-responsive organosilica nanocarrier, realizing the intratumoral GSH-responsive organosilica biodegradation and subsequent controlled release of NO in response to intratumoral GSTπ.
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