期刊
Journal of Materials Chemistry B
标题
Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic
作者
Siming Yu, Kar-Him Luk, Siu-To Cheung, Kevin Wing-Hin Kwok, Ka-Hing Wong and Tianfeng Chen
摘要
Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.
原文链接
https://pubs.rsc.org/en/content/articlelanding/2018/tb/c8tb01084f