期刊
Chinese Journal of Chemistry
标题
Electrochemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulation: Application to Total Synthesis of (±)-Hinckdentine A
作者
Zhong-Wei Hou, Hong Yan, Jin-Shuai Song, Hai-Chao Xu
摘要
The cover picture shows an electricity powered dehydrogenative [3+2] annulation reaction of (hetero)arylamines with tethered di-, tri, and tetra-substituted alkenes for the preparation of indoline and azaindoline products. The electrochemical reactions proceed through H2 evolution and thus avoid the use of stoichiometric chemical oxidants. This method, which is applicable to the preparation of highly functionalized (aza)indoline scaffold, enables the total synthesis of (±)-hinckdentine A in 12 steps. More details are discussed in the article by Xu et al. on page 909–915.
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