期刊
Advanced Functional Materials
标题
X-Ray-Responsive Zeolitic Imidazolate Framework-Capped Nanotherapeutics for Cervical Cancer-Targeting Radiosensitization
作者
Shuya Pan, Guanning Huang, Zhengwei Sun, Xin Chen, Xinli Xiang, Wenxiao Jiang, Yanchao Xu, Tianfeng Chen, Xueqiong Zhu
摘要
Cervical Cancer-Targeting Radiosensitization
In article number 2213364, Xueqiong Zhu, Tianfeng Chen, and co-workers report zeolitic imidazolate framework-capped Mn3O4 nanoparticles modified with folic acid with X-ray response properties. This nanoparticle possesses a high oxygen vacancies rate and Mn3+ ratio, promoting H2O2 and glutathione degradation, producing more singlet oxygen under X-ray, increasing reactive oxygen species level, and alleviating hypoxia within the tumor microenvironment. It shows promising potential for anti-cervical cancer therapeutics.
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