期刊
Analytical Chemistry
标题
Interfacial Super-Assembly of Nanofluidic Heterochannels from Layered Graphene and Alumina Oxide Arrays for Label-Free Histamine-Specific Detection
作者
Shan Zhou, Liping Zhang, Lei Xie, Jie Zeng, Beilei Qiu, Miao Yan, Qirui Liang, Tianyi Liu, Kang Liang, Pu Chen, and Biao Kong
摘要
Nanofluidic devices with well-defined channels have shown great potential for biosensing, separation and, energy conversion. Recently, two-dimensional (2D) materials have been widely used for constructing novel nanofluidic devices owing to their high specific surface, abundant surface charge, and low cost. However, 2D-based nanofluidic devices for highly sensitive biosensing have drawn little attention. Herein, we developed a 2D material-based nanofluidic heterochannel with an asymmetric T-mode nanochannel structure and surface charge polarization distribution. This heterochannel was composed of layered graphene oxide modified with Nα, Nα-bis(carboxymethyl)-l-lysine (containing metal-nitrilotriacetic chelates, NTA) and an oxide array (NTA-GO/AAO), which can achieve remarkable selectivity, specificity, and label-free detection of the neurotransmitter histamine based on a metal ion displacement mechanism. A detection limit of 1 nM can be obtained using the NTA-GO/AAO heterochannel. This study provides a simple and label-free platform for developing a 2D-based nanofluidic heterochannel for specific molecular detection.
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