期刊
Angewandte Chemie International Edition
标题
Selective Fluorescence Imaging of Cancer Cells Based on ROS-Triggered Intracellular Cross-Linking of Artificial Enzyme
作者
Yufei Di, Endong Zhang, Zhiwen Yang, Qi Shen, Dr. Xuancheng Fu, Gang Song, Chuanwei Zhu, Prof. Haotian Bai, Prof. Yiming Huang, Prof. Fengting Lv, Prof. Libing Liu, Prof. Shu Wang
摘要
An artificial enzyme that responds to intracellular reactive oxygen species (ROS) was designed through introducing a catalytic histidine residue at one of the thiols of pentaerythritol tetra(3-mercaptopropionate). The artificial enzyme could in situ cross-link to form an assembled structure that could trigger the cleavage of the ester bond of pro-fluorophore and activate the turn-on fluorescence inside cancer cells for selective diagnosis.
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